The 1990–91 West Midlands (Regional) League season was the 91st in the history of the West Midlands (Regional) League, an English association football competition for semi-professional and amateur teams based in the West Midlands county, Shropshire, Herefordshire, Worcestershire and southern Staffordshire.
| Competition: | West Midlands League Premier Division |
| Season: | 1990–91 |
| Winners: | Gresley Rovers |
| Matches: | 462 |
| Total Goals: | 1422 |
| Prevseason: | 1989–90 |
| Nextseason: | 1991–92 |
The Premier Division featured 19 clubs which competed in the division last season, along with three new clubs:
Also, Millfields changed name to West Bromwich Town.