The 1990–91 Midland Football Combination season was the 54th in the history of Midland Football Combination, a football competition in England.
| Competition: | Midland Football Combination Premier Division |
| Season: | 1990–91 |
| Winners: | West Midlands Police |
| Promoted: | Solihull Borough |
| Relegated: | Polesworth North Warwick |
| Matches: | 420 |
| Total Goals: | 1178 |
| Prevseason: | 1989–90 |
| Nextseason: | 1991–92 |
The Premier Division featured 19 clubs which competed in the division last season, along with two new clubs: