| Election Name: | 1988 United States Senate election in Nebraska |
| Country: | Nebraska |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1982 United States Senate election in Nebraska |
| Previous Year: | 1982 |
| Next Election: | 1994 United States Senate election in Nebraska |
| Next Year: | 1994 |
| Election Date: | November 8, 1988 |
| Image1: | Bob Kerrey portrait.gif |
| Nominee1: | Bob Kerrey |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 378,717 |
| Percentage1: | 56.71% |
| Nominee2: | David Karnes |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 278,250 |
| Percentage2: | 41.66% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | David Karnes |
| Before Party: | Republican Party (United States) |
| After Election: | Bob Kerrey |
| After Party: | Democratic Party (United States) |
The 1988 United States Senate election in Nebraska was held on November 8, 1988 to select the U.S. Senator from the state. Republican U.S. Senator David Karnes decided to seek election to his first full term after being appointed to the seat of the late Edward Zorinsky in March 1987, but was defeated by former governor Bob Kerrey in the November general election.[1] This is the last time a Senator from Nebraska lost re-election.