| Election Name: | 1988 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1982 United States Senate election in Missouri |
| Previous Year: | 1982 |
| Next Election: | 1994 United States Senate election in Missouri |
| Next Year: | 1994 |
| Election Date: | November 8, 1988 |
| Image1: | File:JohnDanforth.jpg |
| Nominee1: | John Danforth |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,407,416 |
| Percentage1: | 67.70% |
| Nominee2: | Jay Nixon |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 660,045 |
| Percentage2: | 31.75% |
| Map Size: | 275px |
| U.S. Senator | |
| Before Election: | John Danforth |
| Before Party: | Republican Party (United States) |
| After Election: | John Danforth |
| After Party: | Republican Party (United States) |
The 1988 United States Senate election in Missouri was held on November 8, 1988 to select the U.S. Senator from the state of Missouri. Incumbent Republican U.S. Senator John Danforth won re-election.[1]