| Election Name: | 1988 United States Senate election in Minnesota |
| Country: | Minnesota |
| Flag Image: | File:Flag of Minnesota (1983-2024).svg |
| Flag Year: | 1983 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1982 United States Senate election in Minnesota |
| Previous Year: | 1982 |
| Next Election: | 1994 United States Senate election in Minnesota |
| Next Year: | 1994 |
| Election Date: | November 8, 1988 |
| Image1: | DavidDurenberger.jpg |
| Nominee1: | David Durenberger |
| Party1: | Independent-Republican Party |
| Popular Vote1: | 1,176,210 |
| Percentage1: | 56.18% |
| Nominee2: | Skip Humphrey |
| Party2: | Minnesota Democratic-Farmer-Labor Party |
| Popular Vote2: | 856,694 |
| Percentage2: | 40.92% |
| Map Size: | 280px |
| U.S. Senator | |
| Before Election: | David Durenberger |
| Before Party: | Independent-Republican Party |
| After Election: | David Durenberger |
| After Party: | Independent-Republican Party |
The 1988 United States Senate election in Minnesota was held on November 8, 1988. Incumbent Republican U.S. Senator David Durenberger won re-election to his third term. He was challenged by democratic Hubert "Skip" Humphrey III, the son of former vice president Hubert Humphrey. The seat had previously been held by both of Skip Humphrey's parents. This is the last time that Minnesota voted for a Senate candidate and a presidential candidate of different political parties as Durenberger, a liberal Republican, remained popular among Minnesotans during his tenure in the Senate.