| Election Name: | 1988 United States Senate election in Maine |
| Country: | Maine |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1982 United States Senate election in Maine |
| Previous Year: | 1982 |
| Next Election: | 1994 United States Senate election in Maine |
| Next Year: | 1994 |
| Election Date: | November 8, 1988 |
| Image1: | George John Mitchell.jpg |
| Nominee1: | George Mitchell |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 452,581 |
| Percentage1: | 81.29% |
| Nominee2: | Jasper Wyman |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 104,164 |
| Percentage2: | 18.71% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | George J. Mitchell |
| Before Party: | Democratic Party (United States) |
| After Election: | George J. Mitchell |
| After Party: | Democratic Party (United States) |
The 1988 United States Senate election in Maine was held on November 8, 1988. Incumbent Democratic U.S. Senator George J. Mitchell won re-election to a second full term in a landslide. As of 2023, this is the last time a Democrat has won a U.S. Senate election in Maine. Incumbent Vice President George H.W. Bush won the state in the concurrent presidential election.