| Year: | 1988 |
| Team: | Ole Miss Rebels |
| Sport: | football |
| Conference: | Southeastern Conference |
| Short Conf: | SEC |
| Record: | 5–6 |
| Conf Record: | 3–4 |
| Head Coach: | Billy Brewer |
| Hc Year: | 6th |
| Off Coach: | Red Parker |
| Oc Year: | 1st |
| Def Coach: | Robert Henry |
| Dc Year: | 1st |
The 1988 Ole Miss Rebels football team represented the University of Mississippi as a member of the Southeastern Conference during the 1988 NCAA Division I-A football season. Led by sixth-year head coach Billy Brewer, the Rebels compiled an overall record of 5–6 with a mark of 3–4 in conference play, tying for sixth place in the SEC.