Defending champion Boris Becker defeated Emilio Sánchez in the final, 7 - 5, 6 - 4, 2 - 6, 6 - 4 to win the singles title at the 1988 Newsweek Champions Cup.
The top eight seeds received a bye into the second round.
Stefan Edberg (third round)
Pat Cash (semifinals)
Tim Mayotte (second round)
Martín Jaite (second round) Andre Agassi (semifinals)
Emilio Sánchez (final) David Pate (third round) Eliot Teltscher (second round)
Amos Mansdorf (quarterfinals) Eduardo Bengoechea (third round) Peter Lundgren (first round) Mikael Pernfors (quarterfinals) Jimmy Arias (first round)