| National Challenge Cup | |
| Year: | 1988 |
| Country: |  United States |
| Winners: | St. Louis Busch Seniors |
| Second: | Greek-American A.C. |
| Prev Season: | 1987 |
| Next Season: | 1989 |
The 1988 National Challenge Cup was the 75th edition of the national soccer championship of the United States.
April 24 Spartans SC (DC/VA) 3:2 Philadelphia Inter (East PA)
May 1 NY Pancyprian Freedoms (East NY) 2:1 Hellenic SC (MA)
Date ? St. Louis Busch SC (MO) W:L Madison 56ers (WI)
Date ? Udinese SC (MO) W:L Ayulta (IL)
Date ? Dallas Mean Green (North TX) W:L Galveston International (South TX)
Date ? Soccer City (GA) W:L ??
May 21 Greek-American A.C. (North CA) W:L Fresno International (North CA)
Date ? King Taco (South CA) W:L ??
Result
Date ? NY Pancyprian Freedoms (East NY) 3:0 Spartans SC (DC/VA)
Date ? St. Louis Busch SC (MO) 4:0 Udinese SC (MO)
Date ? Dallas Mean Green (North TX) 2:0 Soccer City (GA)
Date ? Greek-American A.C. (North CA) 1:0 King Taco (South CA)
(St. Louis Soccer Park – Fenton, Mo.)
June 10 St. Louis Busch SC (MO) 2:0 Dallas Mean Green (North TX)
June 10 Greek-American A.C. (North CA) 3:2 NY Pancyprian Freedoms (East NY)
St. Louis Soccer Park – Fenton, Mo.
June 25 St. Louis Busch SC (MO) 2:1 (AET) Greek-American A.C. (North CA)