| Year: | 1985–86 |
| Record: | 22–11 |
| Sport: | Basketball |
| Conference: | Big Eight Conference |
| Short Conf: | Big Eight |
| Team: | Iowa State Cyclones |
| Head Coach: | Johnny Orr |
| Conf Record: | 9–5 |
| Hc Year: | 6th |
| Asst Coach1: | Steve Antrim |
| Stadium: | Hilton Coliseum |
| Tourney: | NCAA Tournament |
| Tourney Result: | Sweet Sixteen |
The 1985–86 Iowa State Cyclones men's basketball team represented Iowa State University during the 1985–86 NCAA Division I men's basketball season. The Cyclones were coached by Johnny Orr, who was in his 6th season. They played their home games at Hilton Coliseum in Ames, Iowa.
They finished the season 22–11, 9–5 in Big Eight play to finish in 2nd place. The Cyclones advanced to the Big Eight tournament championship game against #2 Kansas, falling 73–71. They qualified for the NCAA Tournament as a 7 seed, defeating 10-seed Miami (Ohio) and 2-seed Michigan before falling to 6-seed NC State in the Sweet Sixteen.
|-!colspan=6 style=""|Regular Season|-!colspan=6 style=""|Exhibition|-!colspan=6 style=""|Regular Season|-!colspan=6 style=""|Big Eight tournament|-!colspan=6 style=""|NCAA Tournament|-[2]
See also: 1986 NBA draft.
| 2 | 46 | Phoenix Suns |