| Score: | 4–6, 7–6(7–2), 6–3 |
| Draw: | 48 (3) |
| Seeds: | 8 |
| Type: | grand slam |
See main article: 1981 Wimbledon Championships. Frew McMillan and Betty Stöve defeated the defending champions John and Tracy Austin in the final, 4–6, 7–6(7–2), 6–3 to win the mixed doubles tennis title at the 1981 Wimbledon Championships.[1]
See also: 1 and 1. 
John Austin / Tracy Austin (final)
See also: 2 and 4. Frew McMillan / Betty Stöve (champions)
See also: 3 and 2. Marty Riessen / 
Wendy Turnbull (third round)
See also: 4. n/a
See also: 5 and 3. Mark Edmondson / Dianne Fromholtz (first round)
See also: 6 and 2. Steve Denton / Anne Smith (first round)
See also: 7 and 4. Kevin Curren / Tanya Harford (quarterfinals)
See also: 8. n/a