| Champ: |  Zina Garrison |
| Runner: | Rene Uys |
| Score: | 6–4, 3–6, 6–0 |
| Before Name: | Wimbledon Championships – Girls' singles |
| After Name: | Wimbledon Championships – Girls' singles |
| Type: | grand slam |
See main article: 1981 Wimbledon Championships. Zina Garrison defeated Rene Uys in the final, 6–4, 3–6, 6–0 to win the girls' singles tennis title at the 1981 Wimbledon Championships.[1]
See also: 1 and 1. Bonnie Gadusek (third round)
See also: 2 and 4. 
Elizabeth Sayers (semifinals)
See also: 3 and 2. Anne Minter (quarterfinals)
See also: 4 and 3. Helena Suková (second round)
See also: 5 and 2. 
Corinne Vanier (third round)
See also: 6 and 4. 
Andrea Temesvári (quarterfinals)
See also: 7. n/a
See also: 8 and 3. Zina Garrison (champion)