| 1981 Waterford Senior Hurling Championship | |
| Champions: | Mount Sion |
| Count: | 25 |
| Runners-Up: | Dunhill |
| Previous Year: | 1980 |
| Previous Tournament: | 1980 Waterford Senior Hurling Championship |
| Next Year: | 1982 |
| Next Tournament: | 1982 Waterford Senior Hurling Championship |
The 1981 Waterford Senior Hurling Championship was the 81st staging of the Waterford Senior Hurling Championship since its establishment by the Waterford County Board in 1897.
Tallow were the defending champions.
On 4 October 1981, Mount Sion won the championship after a 4–13 to 1–14 defeat of Dunhill in the final.[1] This was their 25th championship title overall and their first title since 1975.