| Election Name: | 1981 St. Louis mayoral election |
| Flag Image: | Flag of St. Louis, Missouri.svg |
| Previous Election: | 1977 St. Louis mayoral election |
| Previous Year: | 1977 |
| Election Date: | April 7, 1981 |
| Next Election: | 1985 St. Louis mayoral election |
| Next Year: | 1985 |
| Turnout: | 24.36% |
| Candidate1: | Vincent C. Schoemehl |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 73,219 |
| Percentage1: | 66.38% |
| Candidate2: | Jerry Wamser |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 37,078 |
| Percentage2: | 33.62% |
| Ongoing: | No |
| Map Size: | 200px |
| Mayor | |
| Before Election: | James F. Conway |
| Before Party: | Democratic Party (United States) |
| After Election: | Vincent C. Schoemehl |
| After Party: | Democratic Party (United States) |
The 1981 St. Louis mayoral election was held on April 7, 1981[1] to elect the mayor of St. Louis, Missouri. It saw the election of Vincent C. Schoemehl and the defeat of incumbent mayor James F. Conway in the Democratic primary.
The election was preceded by party primaries on March 3.[2]