See also: 1981 Soviet Second League.
| Season: | 1981 |
| Promoted: | none (after playoffs) |
| Relegated: | none (some teams withdrawn) |
| League Topscorer: | 22 - (Nyva) |
| Nextseason: | 1982 |
1981 Football Championship of Ukrainian SSR was the 51st season of association football competition of the Ukrainian SSR, which was part of the Soviet Second League in Zone 5. The season started on 4 April 1981.
The 1981 Football Championship of Ukrainian SSR was won by Kryvbas Kryvyi Rih. Qualified for the interzonal playoffs, the team from Dnipropetrovsk Oblast did not manage to gain promotion by placing second in its group.
The "Ruby Cup" of Molod Ukrayiny newspaper (for the most scored goals) was received by Kryvbas Kryvyi Rih.
The following were the top ten goalscorers.
| Scorer | Goals (Pen.) | Team | ||
|---|---|---|---|---|
| 1 | 22 | Nyva Vinnytsia | ||
| 2 | Vitaliy Dmytrenko | 21 | Kryvbas Kryvyi Rih | |
| 3 | Fedir Vasylchenko | 20 | Vuhlyk Horlivka | |
| 4 | Oleksandr Novikov | 19 | Kolos Mezhyrich | |
| 5 | Pavlo Petrov | 17 | Atlantyka Sevastopol | |
| 6 | Volodymyr Chyrkov | align=center rowspan=2 | 16 | Avanhard Rivno |
| Vilhelm Tellinher | Podillia Khmelnytskyi |