| Competition: | Segunda División |
| Season: | 1981 |
| Winners: | Deportes Arica |
| Relegated: | None |
| League Topscorer: | Sergio Salgado (27 goals) Cobresal |
| Prevseason: | 1980 |
| Nextseason: | 1982 |
The 1981 Segunda División de Chile was the 30th season of the Segunda División de Chile.
Deportes Arica was the tournament's champion.[1]