| Competition: | Campeonato Nacional 1981 |
| Dates: | 11 July 1981 – 24 January 1982 |
| Winners: | Colo-Colo (13th title) |
| Relegated: | Ñublense Everton Deportes Concepción San Luis |
| Matches: | 240 |
| Total Goals: | 661 |
| Continentalcup1: | 1982 Copa Libertadores |
| Continentalcup1 Qualifiers: | Colo-Colo Cobreloa (Liguilla winners) |
| League Topscorer: | Carlos Caszely Luis Marcoleta Víctor Cabrera (20 goals) |
| Highest Attendance: | 74,570 |
| Attendance: | 1,991,278 |
| Average Attendance: | 8,567 |
| Prevseason: | 1980 |
| Nextseason: | 1982 |
The 1981 Campeonato Nacional was Chilean league top tier's 49th season. Colo-Colo was the tournament's champion, winning its thirteenth title.[1]
| Name | Team | Goals | |
|---|---|---|---|
| Carlos Caszely | Colo-Colo | 20 | |
| Luis Marcoleta | Magallanes | 20 | |
| Víctor Cabrera | San Luis | 20 |
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