| 1981 LPGA Championship | |
| Dates: | June 11–14, 1981 |
| Location: | Mason, Ohio |
| Course: | Jack Nicklaus Golf Center Grizzly Course |
| Tour: | LPGA Tour |
| Par: | 72 |
| Yardage: | [1] |
| Format: | Stroke play - 72 holes |
| Cut: | 149 (+5) |
| Purse: | $150,000 |
| Winners Share: | $22,500 |
| Champion: |  Donna Caponi |
| Score: | 280 (−8) |
| Previous: | 1980 |
| Next: | 1982 |
The 1981 LPGA Championship was the 27th LPGA Championship, played June 11–14 at Jack Nicklaus Golf Center at Kings Island in Mason, Ohio, a suburb northeast of Cincinnati.
Donna Caponi sank a 15adj=onNaNadj=on birdie putt on the final green to win her second LPGA Championship, a stroke ahead of runners-up Jerilyn Britz and Pat Meyers. It was Caponi's fourth and final
Sunday, June 14, 1981
| Place | Player | Score | To par | Money ($) | |||
|---|---|---|---|---|---|---|---|
| 1 | Donna Caponi | 69-68-70-73=280 | −8 | 22,500 | |||
| align=center rowspan=2 | T2 | 67-71-71-72=281 | align=center rowspan=2 | −7 | align=center rowspan=2 | 12,600 | |
| 68-70-72-71=281 | |||||||
| 4 | 72-72-69-70=283 | −5 | 7,500 | ||||
| align=center rowspan=3 | T5 | 72-69-73-70=284 | align=center rowspan=3 | −4 | align=center rowspan=3 | 5,350 | |
| 72-70-71-71=284 | |||||||
| 70-72-72-70=284 | |||||||
| 8 | 71-77-69-68=285 | −3 | 4,350 | ||||
| 9 | 69-70-73-74=286 | −2 | 4,050 | ||||
| align=center rowspan=2 | T10 | 69-74-72-72=287 | align=center rowspan=2 | −1 | align=center rowspan=2 | 3,600 | |
| 73-70-72-72=287 |