The 1981 Family Circle Cup was a women's tennis tournament played on outdoor clay courts at the Sea Pines Racquet Club on Hilton Head Island, South Carolina in the United States that was part of the 1981 Avon Championships World Championship Series. It was the ninth edition of the tournament and was held from April 7 through April 12, 1981. First-seeded Chris Evert won the singles title and earned $30,000 first-prize money.[1] [2]
Chris Evert defeated Pam Shriver 6–3, 6–2
Rosemary Casals / 
'Wendy Turnbull defeated Mima Jaušovec / Pam Shriver 7–5, 7–5
| Event | W | F | 3rd | 4th | QF | Round of 16 | Round of 32 | Round of 64 | ||
| style=background:#efefef | Singles | $30,000 | $15,000 | $7,600 | $7,200 | $3,260 | $1,625 | $800 | $350 |
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