The 1981 Donnay Open was a men's tennis tournament played on outdoor clay courts at the Nice Lawn Tennis Club in Nice, France, and was part of the 1981 Volvo Grand Prix. It was the 10th edition of the tournament and was held from 6 April until 4 April 1981. First-seeded Yannick Noah won the singles title.
Yannick Noah defeated 
Mario Martínez 6–4, 6–2
Pascal Portes / Yannick Noah defeated 
Chris Lewis / Pavel Složil 4–6, 6–3, 6–4