| Copa del Rey | |
| Year: | 1980–81 |
| Other Titles: | 79th Copa del Rey |
| Country: |  Spain |
| Dates: | 10 September 1980 – |
| Num Teams: | 138 |
| Winners: | FC Barcelona |
| Second: | Sporting de Gijón |
| Matches: | 273 |
| Goals: | 781 |
| Prev Season: | 1979–80 |
| Next Season: | 1981–82 |
The 1980–81 Copa del Rey was the 79th staging of the Spanish Cup, the annual domestic cup competition in the Spanish football. The tournament was attended by 138 teams from the main categories of Spanish football.
The tournament began on 10 September 1980 and ended on 18 June 1981 with the final, held in Vicente Calderón Stadium in Madrid, in which the FC Barcelona was crowned for the nineteenth time in their history, after beating Sporting de Gijón 3–1.
The defending champions, Real Madrid CF, were defeated 4–3 (on aggregate score) by Sporting de Gijón on their way to reach their first final.
| Round | Fixture | Clubs | Gain entry |
|---|---|---|---|
| First round | 66 | 138 → 72 | All Clubs participating gain entry |
| Second round | 35 | 72 → 37 | FC Barcelona, Castilla CF, Sporting de Gijón, Valencia CF (*) |
| Third round | 18 | 37 → 19 | Real Sociedad (*) |
| Fourth round | 3 | 19 → 16 | |
| Round of 16 | 8 | 16 → 8 | Real Madrid CF (*) |
| Quarter-finals | 4 | 8 → 4 | |
| Semi-finals | 2 | 4 → 2 | |
| Final | 1 | 2 → 1 |
| 1ª División | 18 | |
| 2ª División | 20 | |
| 2ª División B | 28 | |
| 3ª División | 72 | |
| Total teams | 138 |
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See main article: 1981 Copa del Rey Final.