The 1981 Campionati Internazionali di Sicilia, also known as the Sicilian Grand Prix, was a men's tennis tournament played on outdoor clay courts in Palermo, Italy that was part of the 1981 Volvo Grand Prix. It was the third edition of the tournament and took place from 14 September until 20 September 1981. Unseeded Manuel Orantes won the singles title.
See main article: 1981 Campionati Internazionali di Sicilia – Singles. 
Manuel Orantes defeated Pedro Rebolledo 6–4, 6–0, 6–0
See main article: 1981 Campionati Internazionali di Sicilia – Doubles. José Luis Damiani / Diego Pérez defeated Jaime Fillol / Belus Prajoux 6–1, 6–4