| Competition: | Campeonato Profesional |
| Season: | 1981 |
| Winners: | Atlético Nacional (4th title) |
| Matches: | 365 |
| Total Goals: | 925 |
| League Topscorer: | Víctor Hugo del Río (29) |
| Prevseason: | 1980 |
| Nextseason: | 1982 |
The 1981 Campeonato Profesional was the thirty-fourth season of Colombia's top-flight football league. Junior won the league for the fourth time after winning the Cuadrangular final.[1]