| Competition: | Cypriot First Division |
| Season: | 1981–82 |
| Winners: | Omonia (11th title) |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Omonia (1st round) |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Pezoporikos (1st round) |
| Continentalcup3: | Cup Winners' Cup |
| Continentalcup3 Qualifiers: | Apollon (1st round; via Cypriot Cup) |
| League Topscorer: | Sotiris Kaiafas (19 goals)[1] |
| Matches: | 182 |
| Total Goals: | 414 |
| Prevseason: | 1980–81 |
| Nextseason: | 1982–83 |
The 1981–82 Cypriot First Division was the 43rd season of the Cypriot top-level football league. Omonia won their 11th title.
Fourteen teams participated in the 1981–82 Cypriot First Division. All teams played against each other twice, once at their home and once away. The team with the most points at the end of the season crowned champions. The last two teams were relegated to the 1982–83 Cypriot Second Division.
The champions ensured their participation in the 1982–83 European Cup and the runners-up in the 1982–83 UEFA Cup.
Alki Larnaca and Aris Limassol were relegated from previous season and played in the 1981–82 Cypriot Second Division. They were replaced by the first two teams of the 1980–81 Cypriot Second Division, Evagoras Paphos and APOP Paphos.