| Election Name: | 1980 United States Senate election in Ohio |
| Country: | Ohio |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1974 United States Senate election in Ohio |
| Previous Year: | 1974 |
| Next Election: | 1986 United States Senate election in Ohio |
| Next Year: | 1986 |
| Election Date: | November 4, 1980 |
| Image1: | File:John Glenn Low Res (cropped).jpg |
| Nominee1: | John Glenn |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 2,770,786 |
| Percentage1: | 68.80% |
| Nominee2: | Jim Betts |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 1,137,695 |
| Percentage2: | 28.25% |
| U.S. Senator | |
| Before Election: | John Glenn |
| Before Party: | Democratic Party (United States) |
| After Election: | John Glenn |
| After Party: | Democratic Party (United States) |
| Map Size: | 210px |
The 1980 United States Senate election in Ohio took place on November 4, 1980. It was concurrent with elections to the United States House of Representatives. Incumbent Democratic U.S. Senator John Glenn won re-election to a second term in a landslide with nearly 69% of the vote, coinciding with Ronald Reagan's substantial win in the state during the presidential election. Glenn carried all but one of the state's 88 counties, only losing Paulding County.
Glenn won by a state-record 1.6 million votes.[1] He had also won the largest percentage of the popular vote and received the most votes in any U.S. Senate election in the state's history, and as of 2022 (the most recent senate election), Glenn continues to hold the record of highest percentage of popular vote, with Senator George Voinovich coming close to breaking the record in 2004, receiving 63.9% of the vote (just 4.9% less than Glenn).
Also in 2004, Voinovich, however, would beat Glenn's record of receiving the highest number of votes in an election, receiving nearly 3.47 million votes (nearly 694,000 more votes than Glenn got)[2]