| Election Name: | 1980 United States Senate election in North Carolina |
| Country: | North Carolina |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1974 United States Senate election in North Carolina |
| Previous Year: | 1974 |
| Next Election: | 1986 United States Senate elections in North Carolina |
| Next Year: | 1986 |
| Election Date: | November 4, 1980 |
| Flag Year: | 1885 |
| Image1: | John P. East.jpg |
| Nominee1: | John East |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 898,064 |
| Percentage1: | 49.96% |
| Nominee2: | Robert Morgan |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 887,653 |
| Percentage2: | 49.38% |
| Map: | East: Morgan: |
| U.S. Senator | |
| Before Election: | Robert Morgan |
| Before Party: | Democratic Party (United States) |
| After Election: | John East |
| After Party: | Republican Party (United States) |
The 1980 United States Senate election in North Carolina was held on November 4, 1980, as part of the nationwide elections to the Senate. Incumbent Democratic U.S. Senator Robert Morgan ran for reelection to a second term, but narrowly lost to Republican John East.
This was the first time Republicans won this seat since 1897, and the inauguration of John East marked the first time since 1871 that they held both Senate seats simultaneously.
Robert Morgan was unopposed for the Democratic nomination.
John East was unopposed for the Republican nomination.