| Election Name: | 1980 United States Senate election in Colorado |
| Country: | Colorado |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1974 United States Senate election in Colorado |
| Previous Year: | 1974 |
| Next Election: | 1986 United States Senate election in Colorado |
| Next Year: | 1986 |
| Election Date: | November 4, 1980 |
| Nominee1: | Gary Hart |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 590,501 |
| Percentage1: | 50.33% |
| Nominee2: | Mary Estill Buchanan |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 571,295 |
| Percentage2: | 48.70% |
| U.S. Senator | |
| Before Election: | Gary Hart |
| Before Party: | Democratic Party (United States) |
| After Election: | Gary Hart |
| After Party: | Democratic Party (United States) |
| Map Size: | 250px |
The 1980 United States Senate election in Colorado was held on November 4, 1980. Incumbent Democratic U.S. Senator Gary Hart won re-election to a second term despite Republican nominee Ronald Reagan winning the state over Democratic President Jimmy Carter in the concurrent presidential election. This election was the first time since 1948 that an incumbent Democratic Senator from Colorado was re-elected or won re-election and the first time since 1938 that an incumbent Democratic Senator from Colorado was re-elected or won re-election for this seat.