See main article: article and 1980 US Open (tennis).
Greer Stevens and Bob Hewitt were the defending champions but lost in the quarterfinals to Candy Reynolds and Steve Denton.
Wendy Turnbull and Marty Riessen won in the final 7–5, 6–2 against Betty Stöve and Frew McMillan.
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.