| Champ: |  Jimmy Connors |
| Runner: | John McEnroe |
| Score: | 6–3, 2–6, 6–3, 3–6, 6–4 |
| Draw: | 48 |
| Seeds: | 16 |
| Type: | singles doubles |
See main article: 1980 U.S. Pro Indoor. Jimmy Connors was the defending champion.
Connors successfully defended his title, defeating John McEnroe, 6–3, 2–6, 6–3, 3–6, 6–4 in the final.
Jimmy Connors (champion) John McEnroe (final) Vitas Gerulaitis (second round) Harold Solomon (quarterfinals)
José Higueras (third round) Gene Mayer (semifinals) Peter Fleming (second round)
Wojtek Fibak (quarterfinals)
José Luis Clerc (quarterfinals) Brian Gottfried (third round) Stan Smith (third round) Victor Amaya (second round)
Yannick Noah (first round) Tim Gullikson (third round)