| Year: | 1980 |
| Team: | Southern Miss Golden Eagles |
| Sport: | football |
| Conference: | Independent |
| Record: | 9–3 |
| Head Coach: | Bobby Collins |
| Hc Year: | 6th |
| Stadium: | M. M. Roberts Stadium |
| Champion: | Independence Bowl champion |
| Bowl: | Independence Bowl |
| Bowl Result: | W 16–14 vs. McNeese State |
The 1980 Southern Miss Golden Eagles football team was an American football team that represented the University of Southern Mississippi as an independent during the 1980 NCAA Division I-A football season. In their sixth year under head coach Bobby Collins, the team compiled a 9–3 record.[1]