| Competition: | Segunda División |
| Season: | 1980 |
| Winners: | San Luis de Quillota |
| League Topscorer: | Víctor Cabrera (29 goals) San Luis de Quillota |
| Prevseason: | 1978 |
| Nextseason: | 1981 |
The 1980 Segunda División de Chile was the 29th season of the Segunda División de Chile.
San Luis de Quillota was the tournament's champion.[1]