The 1980 Santiago International Championships was a men's tennis tournament played on outdoor clay courts in Santiago, Chile that was part of the Grand Prix tennis circuit. It was the fifth edition of the tournament and was held from 24 November through 30 November 1980. Third-seeded Víctor Pecci won the singles title.
Víctor Pecci defeated 
Christophe Freyss 4–6, 6–4, 6–3
Ricardo Ycaza / Belus Prajoux defeated 
Carlos Kirmayr / João Soares 4–6, 7–6, 6–4