| Flag Image: | Flag of San Juan, Puerto Rico.svg |
| Country: | Puerto Rico |
| Type: | presidential |
| Previous Election: | 1976 San Juan, Puerto Rico, mayoral election |
| Previous Year: | 1976 |
| Next Election: | 1984 San Juan, Puerto Rico, mayoral election |
| Next Year: | 1984 |
| Election Date: | November 4, 1980 |
| Nominee1: | Hernán Padilla |
| Party1: | New Progressive Party (Puerto Rico) |
| Popular Vote1: | 117,797 |
| Percentage1: | 53.50% |
| Nominee2: | Celeste Benitez |
| Party2: | Popular Democratic Party (Puerto Rico) |
| Popular Vote2: | 86,346 |
| Percentage2: | 39.22% |
| Nominee3: | Roberto Aponte Toro |
| Party3: | Puerto Rican Independence Party |
| Popular Vote3: | 14,767 |
| Percentage3: | 6.71% |
| Mayor | |
| Before Election: | Hernán Padilla |
| Before Party: | New Progressive Party (Puerto Rico) |
| After Election: | Hernán Padilla |
| After Party: | New Progressive Party (Puerto Rico) |
San Juan, Puerto Rico, held an election for mayor on November 4, 1980. It was held as part of the 1980 Puerto Rican general election. It saw the reelection of incumbent mayor Hernán Padilla, a member of the New Progressive Party.