| Season: | 1980 |
| Manager: |  Carlos Alberto Silva |
| Mgrtitle: | Manager |
| Chairman: | Antônio Leme Nunes Galvão |
| Chrtitle: | Chairman |
| League: | Campeonato Brasileiro Série A |
| League Result: | 9th |
| Cup1: | Campeonato Paulista |
| Cup1 Result: | Champions (12th title) |
| League Topscorer: | Serginho (12) |
| Season Topscorer: | Serginho (26) |
| Prevseason: | 1979 |
| Nextseason: | 1981 |
The 1980 season was São Paulo's 51st season since club's existence.
| width=60 | Position | width=60 | Nation | width=60 | Playing position | width=150 | Name | width=80 | Campeonato Brasileiro | width=80 | Campeonato Paulista | width=80 | Others | width=80 | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | FW | Serginho | 12 | 13 | 1 | 26 | ||||||||
| 2 | | DF | Getúlio | 5 | 7 | 1 | 13 | ||||||||
| = | | FW | Zé Sérgio | 4 | 7 | 2 | 13 | ||||||||
| 3 | | FW | Assis | 2 | 7 | 3 | 12 | ||||||||
| 4 | | MF | Renato | 5 | 5 | 1 | 11 | ||||||||
| 5 | | MF | Aílton Lira | 4 | 3 | 2 | 9 | ||||||||
| 6 | | FW | Paulo César | 0 | 5 | 0 | 5 | ||||||||
| 7 | | MF | Zizinho | 1 | 2 | 0 | 3 | ||||||||
| 8 | | MF | Teodoro | 2 | 0 | 0 | 2 | ||||||||
| 9 | DF | Darío Pereyra | 0 | 1 | 0 | 1 | |||||||||
| = | | FW | Edu Bala | 0 | 0 | 1 | 1 | ||||||||
| = | | MF | Heriberto | 0 | 1 | 0 | 1 | ||||||||
| = | | DF | Marião | 0 | 1 | 0 | 1 | ||||||||
| = | | DF | Ney | 0 | 1 | 0 | 1 | ||||||||
| = | | FW | Tatu | 0 | 1 | 0 | 1 | ||||||||
| Own goals | 1 | 1 | 1 | 3 | |||||||||||
| Total | 36 | 55 | 12 | 103 |
| Games played | 71 (44 Campeonato Paulista, 18 Campeonato Brasileiro, 9 Friendly match) |
| Games won | 34 (22 Campeonato Paulista, 8 Campeonato Brasileiro, 4 Friendly match) |
| Games drawn | 24 (13 Campeonato Paulista, 8 Campeonato Brasileiro, 3 Friendly match) |
| Games lost | 13 (9 Campeonato Paulista, 2 Campeonato Brasileiro, 2 Friendly match) |
| Goals scored | 106 |
| Goals conceded | 63 |
| Goal difference | +43 |
| Best result | 4–0 (A) v Palmeiras - Friendly match - 1980.08.05 4–0 (H) v Corinthians - Campeonato Paulista - 1980.08.10 |
| Worst result | 1–3 (H) v Internacional - Friendly match - 1980.02.13 1–3 (H) v Guarani - Campeonato Paulista - 1980.10.08 |
| Top scorer | Serginho Chulapa (26) |