| Year: | 1980 |
| Team: | Missouri Tigers |
| Sport: | football |
| Conference: | Big Eight Conference |
| Short Conf: | Big 8 |
| Record: | 8–4 |
| Conf Record: | 5–2 |
| Head Coach: | Warren Powers |
| Hc Year: | 3rd |
| Stadium: | Faurot Field |
| Bowl: | Liberty Bowl |
| Bowl Result: | L 25–28 vs. Purdue |
The 1980 Missouri Tigers football team represented the University of Missouri as a member of the Big Eight Conference (Big 8) during the 1980 NCAA Division I-A football season. Led by third-year head coach Warren Powers, the Tigers compiled an overall record of 8–4 with a mark of 5–2 in conference play, placing third in the Big 8. Missouri was invited to the Liberty Bowl, where the Tigers lost to Purdue. The team played home game at Faurot Field in Columbia, Missouri.