| Year: | 1980 |
| Team: | Iowa State Cyclones |
| Sport: | football |
| Conference: | Big Eight Conference |
| Short Conf: | Big 8 |
| Record: | 6–5 |
| Conf Record: | 3–4 |
| Head Coach: | Donnie Duncan |
| Hc Year: | 2nd |
| Off Coach: | Mack Brown |
| Oc Year: | 1st |
| Stadium: | Cylcone Stadium |
The 1980 Iowa State Cyclones football team represented Iowa State University as a member of the Big Eight Conference during the 1980 NCAA Division I-A football season. Led by second-year head coach Donnie Duncan, the Cyclones compiled an overall record of 6–5 with a mark of 3–4 in conference play, tying for fourth place in the Big Eight. The team played its home games at Cylcone Stadium in Ames, Iowa.