The Eastern League season began on approximately April 1 and the regular season ended on approximately September 1.
The Holyoke Millers defeated the Waterbury Reds two games to one to win the Eastern League Championship Series.
| Eastern League - Northern Division[1] | |||||
|---|---|---|---|---|---|
| Team | Win | Loss | % | GB | |
| Holyoke Millers | 78 | 61 | .561 | – | |
| Buffalo Bisons | 67 | 70 | .489 | 10.0 | |
| 66 | 71 | .482 | 11.0 | ||
| Glens Falls White Sox | 63 | 74 | .460 | 14.0 | |
| Eastern League - Southern Division | |||||
|---|---|---|---|---|---|
| Team | Win | Loss | % | GB | |
| Bristol Red Sox | 79 | 60 | .568 | – | |
| Reading Phillies | 78 | 61 | .561 | 1.0 | |
| Waterbury Reds | 75 | 64 | .540 | 4.0 | |
| West Haven Whitecaps | 47 | 92 | .338 | 32.0 | |
Notes:
Green shade indicates that team advanced to the playoffs
Bold indicates that team advanced to ELCS
Italics indicates that team won ELCS
Holyoke Millers defeated Buffalo Bisons 2 games to 0.
Waterbury Reds defeated Reading Phillies 2 games to 0.
Holyoke Millers defeated Waterbury Reds 2 games to 1.
| 1980 Eastern League | Regular season | Playoffs | |
|---|---|---|---|
| Total attendance | 579,113 | 12,335 | |
| Total games played | 553 | 7 | |
| Average attendance per game | 1,047 | 1,762 |