| Year: | 1980 |
| Team: | Eastern Kentucky Colonels |
| Sport: | football |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 10–3 |
| Conf Record: | 5–2 |
| Head Coach: | Roy Kidd |
| Hc Year: | 17th |
| Stadium: | Hanger Field |
| Bowl: | NCAA Division I-AA Championship Game |
| Bowl Result: | L 29–31 vs Boise State |
The 1980 Eastern Kentucky Colonels football team represented Eastern Kentucky University as a member of the Ohio Valley Conference (OVC) during the 1980 NCAA Division I-AA football season. Led by 17th-year head coach Roy Kidd, the Colonels compiled an overall record of 10–3, with a mark of 5–2 in conference play, and finished tied for second in the OVC. Eastern Kentucky advanced to the NCAA Division I-AA Championship Game and were defeated by Boise State.