| Year: | 1980 |
| Team: | Duke Blue Devils |
| Sport: | football |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Record: | 2–9 |
| Conf Record: | 1–5 |
| Head Coach: | Shirley Wilson |
| Hc Year: | 2nd |
| Off Coach: | Steve Spurrier |
| Oc Year: | 1st |
| Def Coach: | Cliff Yoshida |
| Dc Year: | 1st |
| Mvp: | John Brinkman |
| Captain: | Ed Brown, Dennis Tabron |
| Stadium: | Wallace Wade Stadium |
The 1980 Duke Blue Devils football team was an American football team that represented Duke University as a member of the Atlantic Coast Conference (ACC) during the 1980 NCAA Division I-A football season. In their second year under head coach Shirley Wilson, the Blue Devils complied an overall record of 2–9, with a conference record of 1–5, and finished seventh in the ACC.