| Year: | 1980 |
| Team: | Delaware State Hornets |
| Sport: | football |
| Conference: | Mid-Eastern Athletic Conference |
| Short Conf: | MEAC |
| Record: | 2–9 |
| Conf Record: | 0–5 |
| Head Coach: | Charles Henderson |
| Hc Year: | 2nd |
| Stadium: | Alumni Stadium |
The 1980 Delaware State Hornets football team represented Delaware State College (now known as Delaware State University) as a member of the Mid-Eastern Athletic Conference (MEAC) during the 1980 NCAA Division I-AA football season. Led by second-year head coach Charles Henderson, the Hornets compiled an overall record of 2–9, with a mark of 0–5 in conference play, and finished sixth in the MEAC.