| Year: | 1980 |
| Team: | Colorado Buffaloes |
| Sport: | football |
| Conference: | Big Eight Conference |
| Short Conf: | Big 8 |
| Record: | 1–10 |
| Conf Record: | 1–6 |
| Head Coach: | Chuck Fairbanks |
| Hc Year: | 2nd |
| Off Coach: | Gene Hochevar |
| Oc Year: | 1st |
| Off Scheme: | Multiple |
| Def Coach: | Doug Knotts |
| Dc Year: | 2nd |
| Def Scheme: | 3–4 |
| Mvp: | Lance Olander |
| Captain: | Charles Davis, Steve Doolittle, Brant Thurston |
| Stadium: | Folsom Field |
The 1980 Colorado Buffaloes football team represented the University of Colorado in the Big Eight Conference during the 1980 NCAA Division I-A football season. Led by second-year head coach Chuck Fairbanks, the Buffaloes finished at 1–10 (1–6 in Big 8, tied for last),[1] their second consecutive losing season, and played home games on campus at Folsom Field in Boulder, Colorado.
Colorado's record in 1980 was the worst in program history, punctuated by an 82–42 home loss to Oklahoma in the conference opener,[2] in which 63 records were set. The sole win was over Iowa State in early November;[3] CU had the same record four years later; the 2012 and 2022 teams each had an additional loss (1–11).