See main article: 1980 Benson and Hedges Open. First-seeded John Sadri defeated Tim Wilkison 6–4, 3–6, 6–3, 6–4 to win the 1980 Benson and Hedges Open singles competition. Wilkison was the defending champion.
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.