| Tourney Name: | African Cup Winners' Cup |
| Year: | 1980 |
| Dates: | April - 7 December 1980 |
| Num Teams: | 28 |
| Confederations: | 1 |
| Champion Other: | TP Mazembe |
| Count: | 1 |
| Second Other: |  Africa Sports |
| Matches: | 48 |
| Goals: | 134 |
| Prevseason: | 1979 |
| Nextseason: | 1981 |
The 1980 season of the African Cup Winners' Cup football club tournament was won by Tout Puissant Mazembe in two-legged final victory against Africa Sports. This was the sixth season that the tournament took place for the winners of each African country's domestic cup. Twenty-eight sides entered the competition, with Dingareh and Ader Club withdrawing before the 1st leg of the first round. No preliminary round took place during this season of the competition.
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