| 1980–81 Premiership | |
| Structure: | National knockout championship |
| Season Champs: | Hull Kingston Rovers |
| Season Champ Name: | Winners |
| Runner-Up Name: | Runner-up |
| Second Place: | Hull F.C. |
| Prevseason Link: | 1979–80 Rugby League Premiership |
| Prevseason Year: | 1979–80 |
| Nextseason Link: | 1981–82 Rugby League Premiership |
| Nextseason Year: | 1981–82 |
The 1980–81 Rugby League Premiership was the seventh staging of the end of season Rugby League Premiership competition.
The final was contested by Hull Kingston Rovers and Hull F.C. at Headingley, Leeds. Hull Kingston Rovers won the match 11–7, and was the first time the club had won the Premiership trophy. The prize money for the winning team was £4,000.
| Date | Home team | Score | Away team | Attendance | |
|---|---|---|---|---|---|
| 26 April 1981 | 8–25 | 4,403 | |||
| 29 April 1981 | 12–14 | 5,224 | |||
| 4 May 1981 | 7–19 | 4,889 | |||
| 6 May 1981 | 14–12 | 13,508 |
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