| Competition: | Liga Leumit |
| Season: | 1980–81 |
| Winners: | Hapoel Tel Aviv 8th title |
| Relegated: | Hapoel Haifa Maccabi Ramat Amidar Hapoel Ramat Gan |
| League Topscorer: | Herzl Fitusi (22) |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The 1980–81 Liga Leumit season saw Hapoel Tel Aviv win the title, and Hapoel Haifa, Maccabi Ramat Amidar, Hapoel Ramat Gan were relegated. Herzl Fitusi of Maccabi Petah Tikva was the league's top scorer with 22 goals.