| Competition: | League of Ireland |
| Season: | 1980–81 |
| Winners: | Athlone Town (1st title) |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
Statistics of League of Ireland in the 1980 - 81 season.
It was contested by 16 teams, and Athlone Town won the championship.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Eugene Davis | Athlone Town | 23 |
| 2 | Brendan Bradley | Sligo Rovers | 18 |
| 3 | Mick Fairclough | Dundalk | 16 |
| 3 | Michael O'Connor | Athlone Town | 16 |
| 5 | Gary Hulmes | Limerick United | 13 |
| 6 | Derek Carthy | St Patrick's Athletic | 12 |
| 6 | Paul Nugent | Shelbourne (5) Drogheda United (7) | 12 |
| 8 | Liam Buckley | Shamrock Rovers | 11 |
| 8 | Leo Flanagan | Dundalk | 11 |
| 8 | Jim Mahon | St Patrick's Athletic | 11 |