| Country: | Switzerland |
| Season: | 1980–81 |
| Division1: | Nationalliga A |
| Champions1: | Zürich |
| Division2: | Nationalliga B |
| Champions2: | Vevey-Sports |
| Division3: | 1. Liga |
| Champions3: | 1. Liga champions: FC Ibach Group 1: FC Monthey Group 2: FC Aurore Bienne Group 3: FC Emmenbrücke Group 4: FC Locarno |
| Domestic: | Swiss Cup |
| Dchampions: | Lausanne-Sport |
| Domestic2: | Swiss League Cup |
| Dchampions2: | Zürich |
| Wdivision1: | Swiss Women's Super League |
| Wchampions1: | SV Seebach Zürich |
| Wdomestic: | Swiss Cup |
| Wdchampions: | SV Seebach Zürich |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
| Flagicon: | yes |
The following is a summary of the 1980–81 season of competitive football in Switzerland.
See main article: 1980–81 Nationalliga A.
See main article: 1980–81 Swiss 1. Liga.
The decider match for second group place was played on 29 June in Näfels FC Locarno win and are promoted to 1981–82 Nationalliga B. FC Altstätten continue to decider for fifth position.
The decider matches for fifth promotion place were played on 28 June and 1 July. FC Altstätten win and are promoted to 1981–82 Nationalliga B. FC Stade Lausanne remain in the division.
The championship decider was played on 28 June in Ibach. FC Ibach win and are 1. Liga champions.
The routes of the finalists to the final were:
--------
See main article: article and Swiss League Cup.
The routes of the finalists to the final were:
------------Note: The return match of the final could not be played until September 1981 due to scheduling problems. Zürich won 2–1 on aggregate
See main article: 1980–81 European Cup.
Basel won 5–1 on aggregate.
Red Star Belgrade won 2–1 on aggregate.
See main article: 1980–81 European Cup Winners' Cup.
Haugar won 3–1 on aggregate.
See main article: 1980 Intertoto Cup.
See main article: 1980–81 UEFA Cup.
Grasshopper won 8–3 on aggregate.
Grasshoppers won 3–2 on aggregate.
3–3 on aggregate; Grasshoppers won 4–3 on penalties.
Sochaux won 2–1 on aggregate.
See main article: 1980–81 UEFA Cup.
Grasshopper won 8–3 on aggregate.
Grasshoppers won 3–2 on aggregate.
3–3 on aggregate; Grasshoppers won 4–3 on penalties.
Sochaux won 2–1 on aggregate.
See main article: 1980 Intertoto Cup.
See main article: 1980 Intertoto Cup.
See main article: 1980 Intertoto Cup.