| Sport: | basketball |
| Year: | 1980–81 |
| Prev Year: | 1979–80 |
| Next Year: | 1981–82 |
| Team: | Wake Forest Demon Deacons |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Coachrank: | 14 |
| Aprank: | 11 |
| Record: | 22–7 |
| Conf Record: | 9–5 |
| Head Coach: | Carl Tacy |
| Arena: | Winston-Salem Memorial Coliseum |
| Tourney: | NCAA Tournament |
| Tourney Result: | Second Round |
The 1980–81 Wake Forest Demon Deacons men's basketball team represented Wake Forest University during the 1980–81 NCAA men's basketball season.