| Year: | 1980–81 |
| Team: | San Francisco Dons |
| Sport: | Basketball |
| Conference: | West Coast Athletic Conference |
| Short Conf: | WCAC |
| Record: | 24–7 |
| Conf Record: | 11–3 |
| Head Coach: | Peter Barry |
| Arena: | War Memorial Gymnasium |
| Champion: | West Coast Athletic Conference champions |
| Tourney: | NCAA Tournament |
The 1980–81 San Francisco Dons men's basketball team represented the University of San Francisco as a member of the West Coast Athletic Conference during the 1980–81 NCAA Division I men's basketball season. The Dons finished the season with a 24–7 record (11–3 WCAC) and received a bid to the NCAA Tournament as No. 9 seed in the West region.
|-!colspan=9 style=| Regular season
|-!colspan=9 style=| NCAA Tournament[1]
See main article: 1980–81 NCAA Division I men's basketball rankings.