| Mode: | Basketball |
| Year: | 1980–81 |
| Prev Year: | 1979–80 |
| Next Year: | 1981–82 |
| Team: | Pittsburgh Panthers |
| Conference: | Eastern 8 |
| Conference Link: | Atlantic 10 Conference |
| Short Conf: | Eastern 8 |
| Record: | 19–12 |
| Conf Record: | 8–5 |
| Hc Year: | 1st |
| Ac1 Year: | 1st |
| Ac2 Year: | 1st |
| Ac3 Year: | 1st |
| Stadium: | Fitzgerald Field House (Capacity: 4,122) |
| Champion: | Eastern 8 tournament champion |
| Bowl Result: | Second Round, L 57–74 vs. North Carolina |
The 1980–81 Pittsburgh Panthers men's basketball team represented the University of Pittsburgh in the 1980–81 NCAA Division I men's basketball season. Led by first year head coach Roy Chipman, the Panthers finished with a record of 19–12.[1] They received an automatic bid to the 1981 NCAA Division I Basketball Tournament where they lost in the second round to North Carolina.